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Secondary Acute Lymphoblastic Leukemia after Hodgkin’s Lymphoma or a Coincidental Association of Two Hematological Malignancies?
Secondary acute lymphoblastic leukaemia (sALL), defined as acute lymphoblastic leukaemia following another malignancy, irrespective of previous treatment, is a rare disease, and its biological characteristics have not been accurately described. We report the case of a 24-year old patient followed for Hodgkin’s lymphoma at our clinic, who develops and is diagnosed, less than a year after obtaining complete remission, as having pro-B acute lymphoblastic leukaemia This case has been a real diagnostic and treatment challenge, as sALL following another haematological malignancy is quite rare. Conclusion: It is necessary to better identify the prognostic factors of haematological malignancies in order to prevent the appearance of sALL.
Keywords: secondary acute leukaemia, Hodgkin’s lymphoma, immunophenotyping, 11q23 mutation, alkilating agents, prognostic factors