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MÆDICA - a Journal of Clinical Medicine | Vol. 11, nr. 4, 2016
ISSN 1841-9038  |  e-ISSN 2069-6116
ISSN-L 1841-9038
CNCSIS - CMR - B+

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Telocytes – a Hope for Cardiac Repair after Myocardial Infarction

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ABSTRACT

Cardiovascular diseases, particularly myocardial infarction, remain the leading cause of morbidity and mortality worldwide, even though pharmacological and interventional therapies improved significantly in the last years. Moreover, despite encouraging results of cell - based therapies in experimental myocardial infarction models, clinical trials showed inconsistent and modest efficiency. Therefore the next step should be the revealing of a new cell type, capable of regenerating the damaged myocardium.
Telocytes (TCs), a relatively new type of interstitial cells, were described few years ago and are credited with important roles in regenerative therapies.
In this paper we review their most important characteristics and functions, showing the evidences of their potential role in cardiac repair and regeneration.
Our research leads to the conclusion that TCs might be a novel target for therapeutic strategies in myocardial infarction.
Keywords: Myocardial infarction, telocytes, regenerative therapies

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