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Clinical Phenotype of Endothelial Dysfunction in Romanian Scleroderma Patients
Laura GROSEANU, Florian BERGHEA, Andra BALANESCU, Denisa PREDETEANU, Violeta BOJINCA, Ioana SAULESCU, Cosmin CONSTANTINESCU, Daniela OPRIS, Mihai ABOBULUI, Andreea BORANGIU, Maria-Magdalena NEGRU, Violeta VLAD and Ruxandra IONESCU
Objective: to identify the particularities of the clinical phenotype of endothelial dysfunction in a lot of Romanian patients from a reference center and compare it to data reported by international registries.
Material and methods: 51 patients were included in a cross-sectional study. The patients were evaluated for the pattern of disease, main visceral involvement, serum markers of disease.
Results: 41.2% patients had history of digital ulcers, 27.45% had pulmonary arterial hypertension; cardiovascular involvement also included: diastolic dysfunction in 31.1% of the patients, global systolic dysfunction in 9.8%, rhythm and conduction disturbances in 19.6%, peripheral vascular disease in 19.6%. Scleroderma renal crisis was identified in 2 patients.
Conclusions: Vascular complications are a major cause of morbidity and mortality in systemic sclerosis. Earlier therapeutic intervention demands improved screening and diagnosis in all cases.