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Epidemiological characteristics of HEPATITIS C and B viral infection in patients with lymphoproliferations sustain their role in lymphomagenesis
Abu Al-Ola AL-GHITI, Tudor ARBANAS and Mircea DICULESCU
Hepatitis B and C viruses (HBV, HCV), besides liver disease, are recognized causes of extrahepatic manifestations. There are sufficient, although controversial data to support HCV implication in lymphomagenesis. For HBV this association has never been proved.
Objectives: To investigate HCV and HBV association with lymphoproliferative disorders and to identify possible mechanisms of viral implication in the pathogenesis of these diseases.
Method: We designed a case control study comparing prevalence of HBV and HCV infection between patients with various types of lymphoproliferation and patients with other hematological diseases.
Results: HCV prevalence in patients with B cell lymphoproliferations was significantly higher than in controls. Non-Hodgkin lymphomas showed the strongest association with HCV, especially those with low grade histology. Multiple myeloma had a very high prevalence of HCV infection. Surprisingly HBV is also associated with lymphoproliferative diseases, particularly with B cell lymphoproliferations, indolent but also aggressive lymphomas.
Keywords: hepatitis C virus, hepatitis B virus, lymphoproliferation