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Secondary Acute Lymphoblastic Leukemia after Hodgkin’s Lymphoma or a Coincidental Association of Two Hematological Malignancies?
Mihaela TEVET, Cornel DRAGAN, Carmen SAGUNA, Doina BARBU and Anca Roxana LUPU
ABSTRACT
Secondary acute lymphoblastic leukaemia (sALL), defined as acute lymphoblastic leukaemia following another malignancy, irrespective of previous treatment, is a rare disease, and its biological characteristics have not been accurately described. We report the case of a 24-year old patient followed for Hodgkin’s lymphoma at our clinic, who develops and is diagnosed, less than a year after obtaining complete remission, as having pro-B acute lymphoblastic leukaemia This case has been a real diagnostic and treatment challenge, as sALL following another haematological malignancy is quite rare. Conclusion: It is necessary to better identify the prognostic factors of haematological malignancies in order to prevent the appearance of sALL.
Keywords: secondary acute leukaemia, Hodgkin’s lymphoma, immunophenotyping, 11q23 mutation, alkilating agents, prognostic factors