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Carmina BUSU

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Articles signed on MÆDICA, JCM:

Paraoxonase 1 – an Update of the Antioxidant Properties of High- Density Lipoproteins

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MÆDICA - a Journal of Clinical Medicine | Vol. 10, nr. 2, 2015

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Paraoxonase 1 – an Update of the Antioxidant Properties of High- Density Lipoproteins

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ABSTRACT

Paraoxonase 1 (PON1) belongs to a family of enzymes with related functions, being the best studied member. PON1 is a HDL-associated protein of which function is to protect LDL particles from oxidative modifications. The status of PON1 is influenced by different genetic, life style and dietary factors. This short review is aimed to present some new aspects regarding the antioxidant properties of PON1 with emphasis on the influence exerted by different factors. Also, a special attention is paid to the relationship between PON1 and low- and high-density lipoproteins in the context of atherosclerosis which affects the endothelial cells.

Keywords: paraoxonase 1, oxidative stress, HDL

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The Relationship Between Alanerv® Consumption and Erythrocytes’ Redox Status in Post-Acute Stroke Patients Undergoing Rehabilitation

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MÆDICA - a Journal of Clinical Medicine | Vol. 9, nr. 3, 2014

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The Relationship Between Alanerv® Consumption and Erythrocytes’ Redox Status in Post-Acute Stroke Patients Undergoing Rehabilitation

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ABSTRACT

Objectives: Stroke is a pathological condition associated with a redox imbalance. Both the acute and the post-acute phases after a stroke are characterized by a pro-oxidant state, which could be corrected through antioxidant supplementation. The aim of the present study was to evaluate the effect of the ALAnerv® upon the redox status of erythrocytes.

Material and Methods: For this pilot study were enrolled 28 post-acute stroke patients. They were randomly divided into a control group [(-) ALA] and a study group [(+) ALA]. Patients were hospitalized for a period of two weeks. Blood samples were taken at the beginning and at the end of this period. Patients from (+) ALA group received the nutritional supplement ALAnerv®. Catalase, SOD, GPx, GRed and GT activities were assessed on erythrocytes’ lysates. Also, the total antioxidant capacity as well as the concentration of total thiols were evaluated.

Outcomes: During the study period only SOD (1393.48 ± 69.14 U/g Hb vs. 1514.06 ± 60.80) and GRed (4.47 ± 0.37 U/g Hb vs. 5.06 ± 0.24) significantly increased in (+) ALA group. Catalase (173.70 ± 14.62 k/g Hb vs. 123.41 ± 8.71) and GT (5.55 ± 0.26 U/g Hb vs. 4.95 ± 0.23) activities significantly decreased during the study period. Multiple regression indicated that only SOD, GT and GRed activities were influenced by the ALAnerv® consumption. There was no significant increase if the total thiols concentration.

Conclusions: ALAnerv® consumption could be associated with a correction of the erythrocytes’ redox status. There is a need to investigate if administration of ALAnerv® over a longer time period could have a more significant influence on the erythrocytes’ antioxidant system.

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