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Cristina TIU

Latest posts by Cristina TIU (see all)

Articles signed on MÆDICA, JCM:

Vertebral Artery Dissection: a Contemporary Perspective

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MÆDICA - a Journal of Clinical Medicine | Vol. 11, nr. 2, 2016 CNCSIS - CMR - B+ OBBCSSR

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Vertebral Artery Dissection: a Contemporary Perspective

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ABSTRACT

Arterial dissections are among the most frequent causes of stroke in young adults. Usually they are associated with trauma, but as the modern imaging tools are evolving, more dissections are being diagnosed and more etiologies are being described. Vertebral artery dissections (VADs) have the distinct particularity that they can cause ischemic stroke (in the brainstem, cerebellum or even the spinal cord), but also subarachnoid hemorrhage, when the dissection occurs in the intracranial segment of the vertebral artery. We present a review of the literature, going over etiology, clinical aspects, diagnosis and treatment of VADs and we illustrate the theory with three different types of VAD from our clinical experience.

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Cardiovascular Dysfunction in Multiple Sclerosis

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MÆDICA - a Journal of Clinical Medicine | Vol. 10, nr. 4, 2015 CNCSIS - CMR - B+ OBBCSSR

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Cardiovascular Dysfunction in Multiple Sclerosis

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ABSTRACT

Multiple sclerosis (MS) is a chronic neurological condition, characterized by recurrent episodes of inflammation and demyelination of the central nervous system called relapsing-remitting episodes, and continuous axonal degeneration that leads to irreversible progressive invalidity.

Patients with multiple sclerosis present a higher mortality rate compared to the general population, and the excess of mortality may be explained by the increased cardiovascular risk and occurrence of cardiovascular disease. However, the exact pathways to cardiovascular dysfunction are not yet completely elucidated.

This review focuses on the most important mechanisms of cardiovascular dysfunction in MS, such as the cardiomyocite structure alteration, the cardiovascular autonomous nervous system dysfunction, physical invalidity, oxidative stress and endothelial dysfunction, as well as the impact of cardiovascular risk factors in MS.

The latest evidence about therapeutic approaches for MS, such as immunomodulatory treatment, vitamin D supplementation and statins are also discussed.

There is little knowledge about the cardiovascular dysfunction in MS, and further research is required to improve the understanding of these complex mechanisms.

Keywords: multiple sclerosis, cardiovascular dysfunction, immunonodulatory treatment

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Endocarditis and Stroke

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MÆDICA - a Journal of Clinical Medicine | Vol. 9, nr. 4, 2014

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Endocarditis and Stroke

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ABSTRACT

Endocarditis is an important, although less common, cause of cerebral embolism. All forms of endocarditis share an initial common pathophysiologic pathway, best illustrated by the non-bacterial thrombotic form, but also a final potential for embolization. Stroke associated with endocarditis has signifficant mortality and morbidity rates, especially due to the frequent concomitant multiple sites of brain embolization.

In this article we aim to briefly review endocarditis with a focus on stroke as a complication, while also presenting case correlates from our department.

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