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Gabriel SAMASCA

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Articles signed on MÆDICA, JCM:

Immunological Evaluation of Surgical Stress in Liver Resections

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MÆDICA - a Journal of Clinical Medicine | Vol. 12, nr. 4, 2017
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Immunological Evaluation of Surgical Stress in Liver Resections

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ABSTRACT

Surgery has its origins in caring for patients suffering from injury or infection. In the last decade, a huge amount of published data has been describing a wide range of conditions resulting from trauma or infection, from minor, local reactions to a surgical operation and leading to a systemic stress response, systemic inflammatory response and finally to multiple organ failure. Our aim was to highlight the main immunological aspects of liver resections. There are many types of liver resections, ranging from small, isolated resections for benign diseases (e.g., small cysts or angyoma) to segmentectomies, bi- or trisegmentectomies to hepatectomies in the end. Patients undergoing such resections are subjected to a large amount of surgical stress and in some cases, postoperative complications ranging from light to severe. The main links between immunology and liver resections is surgical stress that can be evaluated through various immunological methods, which will be presented in this article.
Keywords: cytokines, neutrophils, inflammation, human

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Congenital Lobar Emphysema in Infants

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MÆDICA - a Journal of Clinical Medicine | Vol. 12, nr. 2, 2017
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Congenital Lobar Emphysema in Infants

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ABSTRACT

Congenital lobar emphysema in infants is a disorder that is detected most often in newborns or young infants. We report here the case of a 4-month-old infant who at two months suddenly presented upper respiratory infections, treated symptomatically, but evolution showed shortness of breath, wheezing, weight deficit. Thoracic ultrasound revealed left upper lobe hyperinflation causing mediastinal displacement to the right, a slightly reduced blood supply at this level, and a lobar emphysema appearance. Bronchoscopy evidenced a thickening in the left bronchial tree, due to left upper lobe emphysema.

Keywords: congenital lobar emphysema, congenital lobar emphysema in infants, infant

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An Invasive Treatment of Pseudomyxoma Peritonei with Intrathoracic Involvement

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MÆDICA - a Journal of Clinical Medicine | Vol. 11, nr. 1, 2016 CNCSIS - CMR - B+ OBBCSSR

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An Invasive Treatment of Pseudomyxoma Peritonei with Intrathoracic Involvement

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ABSTRACT

Pseudomyxoma peritonei (PP) is a rare disease characterized by the presence of mucinous ascites and low and progressive accumulation of peritoneal implants. We report the case of a 44-year-old man presented with ascites, imaging evaluations suggesting the diagnosis of gelatinous peritoneal carcinomatosis. The patient underwent laparoscopy with extensive cytoreductive surgery combined with hyperthermic intraoperative peritoneal chemotherapy (HIPEC). Microscopic features confirmed the diagnosis of low-grade PP. Nine months later the patients developed left pleural effusion and cytological examination releaved the intrathoracic extension of PP. The treatment consisted in extensive intrathoracic cytoreductive surgery in combination with hyperthermic intrathoracic chemotherapy perfusion (HITOC). Further surgery was requiered due to intra-abdominal recurrence and finally, the patient developed hepatic and pulmonary metastases treated by systemic chemotherapy, with good tolerability and complete response.

Keywords: pseudomyxoma peeritonei, cytoreductive surgery, hyperthermic intraoperative, peritoneal chemotherapy, hyperthermic intrathoracic chemotherapy perfusion

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Etiological Peculiarities in Pediatric Heart Failure

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MÆDICA - a Journal of Clinical Medicine | Vol. 10, nr. 4, 2015 CNCSIS - CMR - B+ OBBCSSR

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Etiological Peculiarities in Pediatric Heart Failure

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ABSTRACT

Heart failure in children presents important characteristic features different from adult congestive failure, from a pathophysiological and mostly from an etiopathogenic point of view. Heart failure in children is, in most cases, a consequence of congenital structural cardiac abnormalities that remained unoperated, underwent a palliative operation or presented post-surgery complications, or of cardiomyopathy. Based on the nature of the clinical presentation, new onset heart failure can be differentiated from transient heart failure and chronic heart failure. Chronic heart failure may occur in children with biventricular circulation (systolic or diastolic dysfunction), in cardiac structural abnormalities with a right systemic ventricle and in the so-called univentricular heart. Acute heart failure can appear as acute heart failure at onset or as an aggravation of heart failure on the background of acute decompensated chronic heart failure.

Keywords: chronic, acute, causes, biventricular circulation, systemic right ventricle, univentricular circulation

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