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Manole COJOCARU

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Articles signed on MÆDICA, JCM:

New Insights into Antisynthetase Syndrome

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MÆDICA - a Journal of Clinical Medicine | Vol. 11, nr. 2, 2016 CNCSIS - CMR - B+ OBBCSSR

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New Insights into Antisynthetase Syndrome

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ABSTRACT

Antisynthetase syndrome (ASS) is a rare chronic autoimmune disorder (2–3 times more common in women than in men), associated with interstitial lung disease (the most important feature), dermatomyositis (DM), and polymyositis (PM). The cause of ASS is unknown. Recent developments in immunology have improved our knowledge and it is now possible to classify ASS according to the presence of myositis specific autoantibodies. The hallmark of ASS is the presence of serum autoantibodies directed against aminoacyl-tRNA synthetases (anti-ARS involved in protein synthesis). ASS is due to IgG antibodies directed against the enzyme synthase. Antisynthetase antibodies (ASAb) include: anti-histidyl- (anti-Jo-1, being the best known), anti-threonyl- (anti-PL-7), anti-alanyl (anti-PL-12), anti-isoleucyl- (anti-OJ), anti-glycyl- (anti-EJ), anti-asparaginyl- (anti-KS), anti-Wa, anti-tyrosil-(anti-YRS), anti-phenylalanyl-transfer RNA synthetase (anti-Zo), and anti-signal recognition particle (anti-SRP). Anti-Jo-1 is the most common ASAb (in ~20-30% of PM/DM patients).

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Liver Involvement in Patients with Systemic Autoimmune Diseases

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MÆDICA - a Journal of Clinical Medicine | Vol. 8, nr. 4, 2013

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What is plagiarism

Plagiarism’s meaning comes from the Latin word ‘plagiarius,’ which means to kidnap. When someone uses the work of another writer or artist without properly citing the source or giving credit, that’s plagiarism. [...]

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A forum for responsible and ethical research publishing – Code of Conduct and Best Practice Guidelines for Journal Editors.

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Liver Involvement in Patients with Systemic Autoimmune Diseases

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ABSTRACT

A wide variety of systemic autoimmune diseases (SAD) affects the liver, and various forms of hepatic involvement have been reported. Patients who have SAD, the abnormal liver function tests might be caused by SAD. In most of these patients, SAD should be treated primary. Liver involvement in SAD is a matter of great clinical challenge evoking several questions upon diagnostic criteria for liver diseases and the presence of overlap syndromes. This review will describe liver injury caused by various systemic autoimmune diseases.

Keywords: systemic autoimmune diseases, liver, laboratory tests

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Peripheral Nervous System Manifestations in Systemic Autoimmune Diseases

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MÆDICA - a Journal of Clinical Medicine | Vol. 9, nr. 3, 2014

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Peripheral Nervous System Manifestations in Systemic Autoimmune Diseases

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ABSTRACT

The peripheral nervous system refers to parts of the nervous system outside the brain and spinal cord. Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications of these disorders can result in significant morbidity and mortality. The most common complication of peripheral nervous system (PNS) involvement is peripheral neuropathy, with symptoms of numbness, sensory paresthesias, weakness, or gait imbalance. The neuropathy may be multifocal and asymmetric or, less frequently, distal and symmetric.

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