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Relationship between Tumor Infiltrating Lymphocytes and Progression in Breast Cancer
The immune system is very critical in suppression of cancer development. The composition of breast cancer-infiltrating lymphocytes has been widely investigated so far and it is accepted that the presence of high tumor-infiltrating lymphocytes (TILs) is associated with improved prognoses. The correlation between various TIL subpopulations and experimentally observed responses is still characterized by a certain grade of controversy. Modulating the immune system is promising treatment strategy in breast cancer, particularly in HER2 positive and triple-negative molecular subtypes. However, there is still much to be done to implement immunotherapy in this disease.
Keywords: tumor-infiltrating lymphocytes, breast cancer, immunotherapy, HER2