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Relationship between Tumor Infiltrating Lymphocytes and Progression in Breast Cancer
Anca ZGURA, Laurentia GALES, Elvira BRATILA and Rodica ANGHEL
ABSTRACT
The immune system is very critical in suppression of cancer development. The composition of breast cancer-infiltrating lymphocytes has been widely investigated so far and it is accepted that the presence of high tumor-infiltrating lymphocytes (TILs) is associated with improved prognoses. The correlation between various TIL subpopulations and experimentally observed responses is still characterized by a certain grade of controversy. Modulating the immune system is promising treatment strategy in breast cancer, particularly in HER2 positive and triple-negative molecular subtypes. However, there is still much to be done to implement immunotherapy in this disease.
Keywords: tumor-infiltrating lymphocytes, breast cancer, immunotherapy, HER2