Anca Mihaela LAZAROIU

Latest posts by Anca Mihaela LAZAROIU (see all)

Fraser Syndrome – a Case Report and Review of Literature - March 31, 2016
Expression of Bcl-2, Melan A and HMB-45 in Dysplastic Nevi - March 31, 2016
Disseminated CMV and Tuberculosis Infection with Osseous Metaplasia in a Presumable Crohn’s Patient: Case Report - June 30, 2015

Articles signed on MÆDICA, JCM:

Fraser Syndrome – a Case Report and Review of Literature

MÆDICA - a Journal of Clinical Medicine | Vol. 11, nr. 1, 2016

Adrian DUMITRU, Mariana COSTACHE, Anca Mihaela LAZAROIU, George SIMION, Diana SECARA, Monica CIRSTOIU, Alina EMANOIL, Tiberiu Augustin GEORGESCU and Maria SAJIN

ABSTRACT

Fraser syndrome is a rare autosomal recessive genetic disorder characterized by major features such as cryptophthalmos, syndactyly, malformations of the larynx and genitourinary tract, craniofacial dysmorphism, orofacial clefting, mental retardation and musculoskeletal anomalies. In total, about 150 affected patients have been described in the literature. The diagnosis of this syndrome can be established after clinical examination. We present the clinical findings of a rare case of Fraser syndrome with lethal phenotype due to bilateral renal agenesis in a female stillborn.

Keywords: Fraser syndrome, cryptophthalmos, syndactyly, urogenital malformation

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Expression of Bcl-2, Melan A and HMB-45 in Dysplastic Nevi

Oana Maria PATRASCU, Mariana COSTACHE, Adrian Vasile DUMITRU, Corina Nicoleta MEHOTIN, Maria SAJIN and Anca Mihaela LAZAROIU

ABSTRACT

Background: From the first recognition of dysplastic nevi as a pathology per se, many debates have been raised and many histological and immunohistological studies have been conducted in order to establish the true significance of these lesions. Therefore, the aim of this study was to establish if there is a correlation between HMB-45, Melan A and Bcl-2 expression and the grade of dysplasia, as well as between the marker’s staining patterns.

Material and Methods: Ten dysplastic nevi from six female patients were selected and their histological features (size, dysplasia), as well as the immunohistological staining patterns, were studied (HMB-45, Melan A, Bcl-2). The Pearson correlation coefficient and regression was calculated with Windows Excel Data Analysis.

Results: We demonstrated that there was a notable correlation between the dysplasia and the size of the lesions (r(8)= 0.62 with p-value= 0.052), and also between Melan A and Bcl-2 (a r(6)= 0.73, p<0.05), but we did not obtain a statistically significant correlation between other features (p>0.05).

Conclusions: We can affirm, at least in our cases, there is a correlation between the grade of dysplasia and the size of the lesion, and also, that there is a correlation between Melan A and Bcl-2 staining, explained by MITF gene. These results were only partial concordant with those in other studies, therefore a larger number of cases is recommended to be further analyzed in order to clearly draw a conclusion.

Keywords: dysplastic nevi, Bcl-2, Melan A, HMB-45, imunohistological stains

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Disseminated CMV and Tuberculosis Infection with Osseous Metaplasia in a Presumable Crohn’s Patient: Case Report

Oana Maria PATRASCU, Monica CIRSTOIU, Anca Mihaela LAZAROIU, Adrian Vasile DUMITRU, Andreea Elena MIHAI, Manuela POPA, Anca DIMITRIU, Maria SAJIN, Mariana COSTACHE and Andreea ILIESIU

ABSTRACT

Associations of different pathologies are not uncommon in every day practice, but association of disseminated infections like cytomegalovirus infection and tuberculosis are quite rare and hard to diagnose. Both are infections which appear frequently in immunocompromised patients and have unfavorable prognosis. We present a case of a 62 year old male with a history of Crohn’s disease and tuberculosis which presented with symptoms of relapse and infection. He was treated with immunosuppressive medication and cortisol for the past 6 weeks. Cytomegalovirus (CMV) infection was serologically confirmed. In evolution, he suffered from gastrointestinal hemorrhage and died afterwards due to the hemorrhage and pulmonary infections. Histology confirmed the CMV modification in the lungs and intestines, but also highlighted active and disseminated tuberculosis (TB), bronchopneumonia, osseous metaplasia, hyaline membranes, numerous TB abscesses in the intestinal wall and specific CMV and TB modifications in the liver. The trigger for such important and serious infections remains unclear, for the cause can be represented by the Crohn’s disease per se or only by the immunosuppressive treatment. Also, CMV can trigger modifications in immune system and patients with immune-mediated diseases have an increased risk for TB reactivation.

Keywords: cytomegalovirus, tuberculosis, Crohn’s disease, osseous metaplasia, gastro-intestinal hemorrhage

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A Comparison Between Clinical Diagnosis of Death and Autopsy Diagnosis. A Retrospective Study of 131 Newborns, Stillborns and Aborted Fetuses

Mariana COSTACHE, Monica CIRSTOIU, Andreea CONTOLENCO, Anca Mihaela LAZAROIU, Simion GEORGE, Maria SAJIN and Oana Maria PATRASCU

ABSTRACT

In recent years, the autopsy was considered necessary only in medico-legal cases, or when the clinician requires it to better understand the pathology and cause of death (with the deceased family’s consent). Although it has been shown in numerous studies that the autopsy and the postmortem histopathological examination are the only ones that can diagnose correctly and completely, the autopsy rate is declining. The primary motive of the family in consenting to a perinatal necropsy, may be to determine the cause of death of their child and to be aware of possible complications of their future pregnancy. This study shows the rate of concordance between clinical diagnosis and autopsy diagnosis, and the rate of concordance between macroscopic diagnosis and microscopic findings, pointing out once again the importance and the utility of the autopsy in medical practice.

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Clinical or Postmortem? The Importance of the Autopsy; a Retrospective Study

Mariana COSTACHE, Anca Mihaela LAZAROIU, Andreea CONTOLENCO, Diana COSTACHE, Simion GEORGE, Maria SAJIN and Oana Maria PATRASCU

ABSTRACT

Medicine is continually evolving; the new technologies of diagnosis and treatment continue to improve the life expectancy and lead to new information concerning various pathologies. The autopsy is viewed more and more as an ultimate branch of medicine and used only in extreme cases or for forensic purposes. Nevertheless, many studies, including this one, prove the utility and indispensability of the autopsies, without which a complete and accurate diagnosis cannot be made. Finally, the autopsy followed by histopathological examination of the tissues remains the ultimate and most important step for the apprehension of the diseases and for further evolution of medicine. This study reveals the correspondence rate between the clinical and the postmortem diagnosis, as well as between macroscopic and histopathological diagnosis.

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A Challenging Case of Primary Breast Hodgkin’s Lymphoma

Narcis Octavian ZARNESCU, Andreea ILIESIU, Alexandru PROCOP, Mircea TAMPA, Clara MATEI, Maria SAJIN, Mariana COSTACHE, Adrian DUMITRU and Anca Mihaela LAZAROIU

ABSTRACT

Primary breast lymphoma (PBL) is a rare entity accounting for less than 1% of all breast malignancies. Diagnostic criteria for primary Hodgkin’s lymphoma of the breast are: the presence of sufficient tissue for diagnosis, close interaction between mammary tissue and lymphomatous infiltrate and no evidence or prior diagnosis of widespread lymphoma. Our case illustrates an unusual presentation of Hodgkin’s lymphoma of the breast: clinically as inflammatory breast cancer and core biopsy as granulomatous mastitis, the final diagnosis requiring surgical biopsy. Current information regarding this entity is scant, mainly build upon its rarity. In this paper we assess the clinical presentation, the step-bystep diagnosis, the treatment and the importance of immunohistochemistry in this uncommon condition.

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Anca Mihaela LAZAROIU

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Articles signed on MÆDICA, JCM:

Fraser Syndrome – a Case Report and Review of Literature

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